Medication‐related osteonecrosis of the jaw: a literature review and update
S Kuroshima, FA Al‐Omari, M Sasaki, T Sawase - Genesis, 2022 - Wiley Online Library
Since the initial description of medication‐related osteonecrosis of the jaw (MRONJ) almost
two decades ago, the potential pathophysiology and risk factors have been elaborated on in …
two decades ago, the potential pathophysiology and risk factors have been elaborated on in …
Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …
[HTML][HTML] Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics
T Soma, R Iwasaki, Y Sato, T Kobayashi, E Ito… - Scientific reports, 2022 - nature.com
Invasive dental treatment such as tooth extraction following treatment with strong anti-bone
resorptive agents, including bisphosphonates and denosumab, reportedly promotes …
resorptive agents, including bisphosphonates and denosumab, reportedly promotes …
Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice
R Kozutsumi, S Kuroshima, FA Al-Omari, H Hayano… - Bone, 2023 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a potentially intractable
disease with no definitive pathophysiology and no treatment and prevention strategies. This …
disease with no definitive pathophysiology and no treatment and prevention strategies. This …
[HTML][HTML] Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice
W Du, M Yang, T Kim, S Kim, DW Williams… - International journal of …, 2022 - nature.com
Bacterial infection is a common finding in patients, who develop medication-related
osteonecrosis of the jaw (MRONJ) by the long-term and/or high-dose use of anti-resorptive …
osteonecrosis of the jaw (MRONJ) by the long-term and/or high-dose use of anti-resorptive …
[HTML][HTML] Zoledronate/anti-VEGF neutralizing antibody combination administration increases osteal macrophages in a murine model of MRONJ stage 0-like lesions
H Kaneko, S Kuroshima, R Kozutsumi… - Journal of clinical …, 2023 - mdpi.com
The pathophysiology, pathogenesis, histopathology, and immunopathology of medication-
related osteonecrosis of the jaw (MRONJ) Stage 0 remain unclear, although 50% of MRONJ …
related osteonecrosis of the jaw (MRONJ) Stage 0 remain unclear, although 50% of MRONJ …
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate
S Zhu, Y Cui, W Zhang, Y Ji, L Li, S Luo… - Drug Design …, 2024 - Taylor & Francis
Purpose Zoledronate (ZA) stands as a highly effective antiresorptive agent known to trigger
medication-related osteonecrosis of the jaw (MRONJ). Its clinical dosages primarily …
medication-related osteonecrosis of the jaw (MRONJ). Its clinical dosages primarily …
[HTML][HTML] Non-Invasive Physical Plasma Treatment after Tooth Extraction in a Patient on Antiresorptive Medication Promotes Tissue Regeneration
B Eggers, MB Stope, A Mustea, M Nokhbehsaim… - Applied Sciences, 2022 - mdpi.com
Postoperative tissue regeneration can be negatively affected by bisphosphonate
administration, especially in patients with oncologic diseases. A serious complication of …
administration, especially in patients with oncologic diseases. A serious complication of …
[HTML][HTML] Mitigating jaw osteonecrosis: bioactive glass and pericardial membrane combination in a rat model
AA Pellicano, BM Benites, AFN Paschoa… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Objectives Bisphosphonates (BFs) show clinical effectiveness in managing osteoporosis
and bone metastases but pose risks of bisphosphonate-related jaw osteonecrosis (BRONJ) …
and bone metastases but pose risks of bisphosphonate-related jaw osteonecrosis (BRONJ) …
Involvement of Impaired Angiogenesis and Myelosuppression in Antiresorptive-agent Related Osteonecrosis of the Jaw Mouse Model.
H Igarashi, S Nishizawa, T Miyamoto… - Tokai Journal of …, 2023 - search.ebscohost.com
Objective: To explore the involvement of bone marrow cells and angiogenesis in the
pathogenesis of antiresorptive agent-related osteonecrosis of the jaw (ARONJ). Methods …
pathogenesis of antiresorptive agent-related osteonecrosis of the jaw (ARONJ). Methods …