The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and
signaling. Various oncogenic pathways such as proliferation and evading cell death …

Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective
functions are deemed to be the main cellular defense mechanism against exogenous and …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …