The development of animal models that demonstrate excessive levels of alcohol
consumption has played an important role in advancing our knowledge about …

Developing novel treatments for alcohol use disorders (AUDs) is of paramount importance
for improving patient outcomes and alleviating the suffering related to the disease. A better …

After experiencing a traumatic event people often turn to alcohol to cope with symptoms. In
those with post-traumatic stress disorder (PTSD) and a co-occurring alcohol use disorder …

Abstract The Lipid Invasion Model (LIM) is a new hypothesis for Alzheimer's disease (AD)
which argues that AD is a result of external lipid invasion to the brain, following damage to …

Alcohol use disorder is highly comorbid with other neuropsychiatric disorders such as
depression and anxiety. Importantly, women and men are affected differentially by heavy …

The prefrontal cortex (PFC) is involved in executive (“top-down”) control of behavior and its
function is especially susceptible to the effects of alcohol, leading to behavioral disinhibition …

The prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for
neuroadaptations in alcohol use disorders. Recent advances in genetically encoded …

Background The medial prefrontal cortex (PFC) is crucial for regulating craving and alcohol
seeking in alcohol use disorder (AUD) patients and alcohol seeking in animal models …

Stress is a risk factor that plays a considerable role in the development and maintenance of
alcohol (ethanol) abuse and relapse. Preclinical studies examining ethanol-stress …

This review highlights literature relating the anatomy, physiology, and behavioral
contributions by projections between rodent prefrontal cortical areas and the basolateral …