Activation of the serine–threonine protein kinase AKT has emerged as a central feature of
epithelial–mesenchymal transition (EMT), which is the initial step for metastasis in many …

Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by
reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells …

To identify drivers of sarcoma cancer stem-like cells (CSCs), we compared gene expression
using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma …

Activation of the PI3K (phosphoinositide 3-kinase) pathway is a frequent occurrence in
human tumors and is thought to promote growth, survival, and resistance to diverse …

Medulloblastoma is the most common malignant childhood brain tumor and is associated
with a poor outcome. There is an urgent need to develop novel targeted therapeutic …

Cerebral cavernous malformations (CCMs) are neurovascular abnormalities characterized
by thin, leaky blood vessels resulting in lesions that predispose to haemorrhages, stroke …

Background Epidemiological investigations suggest that patients with heart failure have a
higher incidence of cancer; however, the causal role of cardiac disease on cancer …

Obesity represents a risk factor for certain types of cancer. Leptin, a hormone predominantly
produced by adipocytes, is elevated in the obese state. In the context of breast cancer, leptin …

Melanoma cell metastasis is the main cause of patient death. To develop more effective
strategies for the prevention or treatment of melanoma, we investigated the inhibitory effects …

VEGFs (vascular endothelial growth factors) are a family of conserved disulfide-linked
soluble secretory glycoproteins found in higher eukaryotes. VEGFs mediate a wide range of …