Adults with type 2 diabetes are at an increased risk of developing certain brain or mental
disorders, including stroke, dementia, and depression. Although these disorders are not …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

The rapid increase in metabolic diseases, which occurred in the last three decades in both
industrialized and developing countries, has been related to the rise in sugar-added foods …

The formation of advanced glycation end-products (AGE) in tissues is a physiological
process; however, excessive production and storage are pathological and lead to …

OBJECTIVE Methylglyoxal (MGO) is a reactive dicarbonyl compound and a potential key
player in diabetic cardiovascular disease (CVD). Whether plasma MGO levels are …

Late vascular complications play a prominent role in the diabetes-induced increase in
morbidity and mortality. Diabetes mellitus is recognised as a risk factor driving …

The prevalence of metabolic syndrome and cardiovascular disease has increased and
continues to be the leading cause of mortality worldwide. The etiology of these diseases …

The glyoxalase system in the cytoplasm of cells provides the primary defence against
glycation by methylglyoxal catalysing its metabolism to D-lactate. Methylglyoxal is the …

Liver fibrosis is a common chronic hepatic disease. This study was done to examine the
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …