From the prodromal stage of multiple sclerosis to disease prevention

RA Marrie, M Allegretta, LF Barcellos, B Bebo… - Nature Reviews …, 2022 - nature.com
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …

[HTML][HTML] Disease-induced skeletal muscle atrophy and fatigue

SK Powers, GS Lynch, KT Murphy… - Medicine and science …, 2016 - ncbi.nlm.nih.gov
Numerous health problems including acute critical illness, cancer, diseases associated with
chronic inflammation, and neurological disorders often result in skeletal muscle weakness …

Serum neurofilament light chain levels in patients with presymptomatic multiple sclerosis

K Bjornevik, KL Munger, M Cortese, C Barro… - JAMA …, 2020 - jamanetwork.com
Importance Unrecognized demyelinating events often precede the clinical onset of multiple
sclerosis (MS). Identification of these events at the time of occurrence would have …

[HTML][HTML] Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

MP Pender, PA Csurhes, C Smith, NL Douglas… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Increasing evidence indicates a role for EBV in the pathogenesis of
multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS …

Prodromal symptoms of multiple sclerosis in primary care

G Disanto, C Zecca, S MacLachlan, R Sacco… - Annals of …, 2018 - Wiley Online Library
Objective Early diagnosis and treatment initiation significantly influence long‐term disability
outcome in multiple sclerosis (MS). We aimed at identifying prodromal symptoms of MS in …

[HTML][HTML] Multiple sclerosis and SARS-CoV-2: has the interplay started?

G Bellucci, V Rinaldi, MC Buscarinu, R Reniè… - Frontiers in …, 2021 - frontiersin.org
Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex
interactions between the host's genetic background and several environmental factors that …

[HTML][HTML] A systematic review and meta-analysis of strength training in individuals with multiple sclerosis or Parkinson disease

TM Cruickshank, AR Reyes, MR Ziman - Medicine, 2015 - journals.lww.com
Strength training has, in recent years, been shown to be beneficial for people with Parkinson
disease and multiple sclerosis. Consensus regarding its utility for these disorders …

Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort study

JMA Wijnands, E Kingwell, F Zhu, Y Zhao… - The Lancet …, 2017 - thelancet.com
Background Degenerative processes in neurodegenerative diseases can start years before
clinical manifestation. We aimed to establish whether a multiple sclerosis prodromal period …

Rising incidence of psychiatric disorders before diagnosis of immune-mediated inflammatory disease

RA Marrie, R Walld, JM Bolton, J Sareen… - Epidemiology and …, 2019 - cambridge.org
Aims. After the diagnosis of immune-mediated inflammatory diseases (IMID) such as
inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), the …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …