[HTML][HTML] Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
[HTML][HTML] A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
NR Raval, A Johansen, LL Donovan, NF Ros… - International journal of …, 2021 - mdpi.com
A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT2AR) agonist,
may be associated with antidepressant effects. The mechanism behind its antidepressive …
may be associated with antidepressant effects. The mechanism behind its antidepressive …
[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease
SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …
availability of symptomatic treatments, response towards the health of PD patients remains …
[HTML][HTML] Synaptic pruning by microglia in epilepsy
Structural and functional collapse of the balance between excitatory (E) and inhibitory (I)
synapses, ie, synaptic E/I balance, underlies the pathogeneses of various central nervous …
synapses, ie, synaptic E/I balance, underlies the pathogeneses of various central nervous …
[HTML][HTML] Imaging synaptic density: the next holy grail of neuroscience?
ME Serrano, E Kim, MM Petrinovic… - Frontiers in …, 2022 - frontiersin.org
The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …
of neurons that constantly communicate through trillions of connections called synapses …
[HTML][HTML] Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease
RNA-binding proteins (RBPs) are key players regulating RNA processing and are
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …
Imaging of synaptic density in neurodegenerative disorders
PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …
and other measures of brain function. Recently, a new approach has emerged to image …
Emerging roles of the human solute carrier 22 family
SW Yee, KM Giacomini - Drug Metabolism and Disposition, 2022 - ASPET
The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …