Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung
Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …
consuming process involving numerous disciplines of basic and applied sciences. During …
Not all nebulizers are created equal: Considerations in choosing a nebulizer for aerosol delivery during mechanical ventilation
R MacLoughlin, I Martin-Loeches - Expert Review of Respiratory …, 2023 - Taylor & Francis
Introduction Aerosol therapy is commonly prescribed in the mechanically ventilated patient.
Jet nebulizers (JN) and vibrating mesh nebulizers (VMN) are the most common nebulizer …
Jet nebulizers (JN) and vibrating mesh nebulizers (VMN) are the most common nebulizer …
Validating whole-airway CFD predictions of DPI aerosol deposition at multiple flow rates
PW Longest, G Tian… - Journal of aerosol …, 2016 - liebertpub.com
Background: The objective of this study was to compare aerosol deposition predictions of a
new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) …
new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) …
Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
Effects of anti-T2 biologic treatment on lung ventilation evaluated by MRI in adults with prednisone-dependent asthma
Background The functional consequence of airway obstruction in asthma can be regionally
measured using inhaled gas MRI. Ventilation defects visualized by MRI persist post …
measured using inhaled gas MRI. Ventilation defects visualized by MRI persist post …
A 3D printed human upper respiratory tract model for particulate deposition profiling
Pulmonary route is the main route of drug delivery for patients with asthma and chronic
obstructive pulmonary diseases, offering several advantages over the oral route …
obstructive pulmonary diseases, offering several advantages over the oral route …
Differences in particle deposition between members of imaging-based asthma clusters
Background: Four computed tomography (CT) imaging-based clusters have been identified
in a study of the Severe Asthma Research Program (SARP) cohort and have been …
in a study of the Severe Asthma Research Program (SARP) cohort and have been …
Effect of static vs. dynamic imaging on particle transport in CT-based numerical models of human central airways
Advances in quantitative computed tomography (CT) has provided methods to assess the
detailed structure of the pulmonary airways and parenchyma, providing the means of …
detailed structure of the pulmonary airways and parenchyma, providing the means of …
Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery
Introduction: Aerosol drug delivery to the lungs via inhalation is widely used in the treatment
of respiratory diseases. The deposition pattern of inhaled particles within the airways of the …
of respiratory diseases. The deposition pattern of inhaled particles within the airways of the …
Advances in Structure Pharmaceutics from Discovery to Evaluation and Design
H Xu, L Wu, Y Xue, T Yang, T Xiong… - Molecular …, 2023 - ACS Publications
Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical
ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and …
ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and …