In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Life-like systems need to maintain a basal metabolism, which includes importing a variety of
building blocks required for macromolecule synthesis, exporting dead-end products, and …

Cryopreservation is a process used for the storage of mammalian cells at a very low
temperature, in a state of 'suspended animation.'Highly effective and safe macromolecular …

The spatial organization of cell membrane glycoproteins and glycolipids is critical for
mediating the binding of ligands, receptors, and macromolecules on the plasma membrane …

In multicellular organisms, the intracellular and extracellular spaces are considerably
packed with a diverse range of macromolecular species. Yet, standard eukaryotic cell …

The orchestrated activity of the mitochondrial respiratory or electron transport chain (ETC)
and ATP synthase convert reduction power (NADH, FADH2) into ATP, the cell's energy …

Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …

All protein simulations are conducted with varying degrees of simplification, oftentimes with
unknown ramifications about how these simplifications affect the interpretability of the …

The extent of the effect of cellular crowding and cosolutes on the functioning of proteins and
cells is manifold and includes the stabilization of the biomolecular systems, the excluded …

The development of therapeutic regenerative medicine and accurate drug discovery cell-
based products requires effective, with respect to obtaining sufficient numbers of viable …