With the rising prevalence of kidney disease, clinicians are increasingly faced with concerns
about potential thrombotic and bleeding complications. Thrombotic risk, both arterial and …

Anaemia is an important component of diabetic nephropathy but only recently has it
attracted the attention of diabetologists and nephrologists. In diabetic patients, anaemia is …

Introduction Patients with end-stage renal disease (ESRD) requiring hemodialysis (HD)
have an increased risk of thrombotic events and bleeding. Antisense reduction of factor XI …

In the last 10 years, the concept of biocompatibility as applied to haemodialysis membranes
has gained a general clinical acceptance in light of the knowledge that the clinical …

Background. Binding of polycationic unfractionated heparin onto the modified AN69
polyacrylonitrile membrane, whose surface electronegativity has been neutralized by …

Maintaining patency of the extracorporeal hemodialysis (HD) circuit is a prerequisite to
perform HD. Unfractionated heparin and low-molecular-weight heparins are the most used …

Anticoagulation therapy is commonly required in patients with chronic kidney disease for
treatment or prevention of thromboembolic disorders. Anticoagulant management plans can …

The exposure of blood to an artificial surface such as the haemodialysis membrane results
in the nearly instantaneous deposition of a layer of plasma proteins. The composition of the …

Rationale & Objective The EvoCit study was designed to evaluate performance of a heparin-
grafted dialyzer during hemodialysis with and without systemic anticoagulation. Study …

Abstract Background. The AN69 ST haemodialysis membrane, a new membrane resulting
from coating polyethyleneimine upon the polyacrylonitrile surface, binds heparin. In patients …