Pathogenesis of Alzheimer's disease

AA Rostagno - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia, accounting for 60% to 80%
of all cases. It is estimated that this debilitating neurodegenerative disorder currently affects …

High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?

J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …

Mitochondrial dysfunction: a key player in brain aging and diseases

S Bartman, G Coppotelli, JM Ross - Current Issues in Molecular Biology, 2024 - mdpi.com
Mitochondria are thought to have become incorporated within the eukaryotic cell
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …

Sex-specific transcriptional rewiring in the brain of Alzheimer's disease patients

JA Santiago, JP Quinn, JA Potashkin - Frontiers in Aging …, 2022 - frontiersin.org
Sex-specific differences may contribute to Alzheimer's disease (AD) development. AD is
more prevalent in women worldwide, and female sex has been suggested as a disease risk …

Detection of early Alzheimer's disease‐like molecular alterations in a mouse model expressing human ApoE4

A Rai, OA Ojiakor, RJ Rylett - Journal of Neurochemistry, 2023 - Wiley Online Library
The E4 allele of apolipoprotein E (ApoE4) is a key genetic risk factor for late‐onset
Alzheimer's disease (AD), increasing the risk of developing the disease by up to three‐fold …

Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a …

SE Mackey-Alfonso, MJ Butler, AM Taylor… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative disease characterized by profound
memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers …

Obesity affects brain cortex gene expression in an APOE genotype and sex dependent manner

H Pandit, NS Jones, GW Rebeck - International Journal of Obesity, 2024 - nature.com
Objective Obesity is the top modifiable risk factor for Alzheimer's disease. We hypothesized
that high fat diet (HFD)-induced obesity alters brain transcriptomics in APOE-genotype and …

[HTML][HTML] The Therapeutic Potential of Dalbergia pinnata (Lour.) Prain Essential Oil in Alzheimer's Disease: EEG Signal Analysis In Vivo, SH-SY5Y Cell Model In Vitro …

S Qin, J Fang, X He, G Yu, F Yi, G Zhu - Biology, 2024 - mdpi.com
Simple Summary Simple Summary: Plant essential oils are currently gaining increasing
attention for their roles in mood regulation and neuroprotection. Dalbergia pinnata (Lour.) …

Antioxidant and Hepatoprotective Effect of Rosa davurica Pall Seed Oil on CCl4-Induced Acute Liver Injury in Mice

C Liu, X Yu, M Zhang, S Wang, J Ni… - Journal of Medicinal …, 2024 - liebertpub.com
The liver, being the most metabolically active organ, is highly vulnerable to damage caused
by oxidative stress. Rosa davurica Pall. seed oil (RDPO), a novel vegetable oil, and its …

Vivaria housing conditions expose sex differences in brain oxidation, microglial activation, and immune system states in aged hAPOE4 mice

EM Reyes-Reyes, J Brown, MD Trial… - Experimental Brain …, 2024 - Springer
Apolipoprotein E ε4 allele (APOE4) is the predominant genetic risk factor for late-onset
Alzheimer's disease (AD). APOE4 mouse models have provided advances in the …