Pathogenesis of Alzheimer's disease
AA Rostagno - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia, accounting for 60% to 80%
of all cases. It is estimated that this debilitating neurodegenerative disorder currently affects …
of all cases. It is estimated that this debilitating neurodegenerative disorder currently affects …
High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?
J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
Mitochondrial dysfunction: a key player in brain aging and diseases
S Bartman, G Coppotelli, JM Ross - Current Issues in Molecular Biology, 2024 - mdpi.com
Mitochondria are thought to have become incorporated within the eukaryotic cell
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …
Sex-specific transcriptional rewiring in the brain of Alzheimer's disease patients
JA Santiago, JP Quinn, JA Potashkin - Frontiers in Aging …, 2022 - frontiersin.org
Sex-specific differences may contribute to Alzheimer's disease (AD) development. AD is
more prevalent in women worldwide, and female sex has been suggested as a disease risk …
more prevalent in women worldwide, and female sex has been suggested as a disease risk …
Detection of early Alzheimer's disease‐like molecular alterations in a mouse model expressing human ApoE4
A Rai, OA Ojiakor, RJ Rylett - Journal of Neurochemistry, 2023 - Wiley Online Library
The E4 allele of apolipoprotein E (ApoE4) is a key genetic risk factor for late‐onset
Alzheimer's disease (AD), increasing the risk of developing the disease by up to three‐fold …
Alzheimer's disease (AD), increasing the risk of developing the disease by up to three‐fold …
Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a …
SE Mackey-Alfonso, MJ Butler, AM Taylor… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative disease characterized by profound
memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers …
memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers …
Obesity affects brain cortex gene expression in an APOE genotype and sex dependent manner
Objective Obesity is the top modifiable risk factor for Alzheimer's disease. We hypothesized
that high fat diet (HFD)-induced obesity alters brain transcriptomics in APOE-genotype and …
that high fat diet (HFD)-induced obesity alters brain transcriptomics in APOE-genotype and …
[HTML][HTML] The Therapeutic Potential of Dalbergia pinnata (Lour.) Prain Essential Oil in Alzheimer's Disease: EEG Signal Analysis In Vivo, SH-SY5Y Cell Model In Vitro …
S Qin, J Fang, X He, G Yu, F Yi, G Zhu - Biology, 2024 - mdpi.com
Simple Summary Simple Summary: Plant essential oils are currently gaining increasing
attention for their roles in mood regulation and neuroprotection. Dalbergia pinnata (Lour.) …
attention for their roles in mood regulation and neuroprotection. Dalbergia pinnata (Lour.) …
Antioxidant and Hepatoprotective Effect of Rosa davurica Pall Seed Oil on CCl4-Induced Acute Liver Injury in Mice
C Liu, X Yu, M Zhang, S Wang, J Ni… - Journal of Medicinal …, 2024 - liebertpub.com
The liver, being the most metabolically active organ, is highly vulnerable to damage caused
by oxidative stress. Rosa davurica Pall. seed oil (RDPO), a novel vegetable oil, and its …
by oxidative stress. Rosa davurica Pall. seed oil (RDPO), a novel vegetable oil, and its …
Vivaria housing conditions expose sex differences in brain oxidation, microglial activation, and immune system states in aged hAPOE4 mice
EM Reyes-Reyes, J Brown, MD Trial… - Experimental Brain …, 2024 - Springer
Apolipoprotein E ε4 allele (APOE4) is the predominant genetic risk factor for late-onset
Alzheimer's disease (AD). APOE4 mouse models have provided advances in the …
Alzheimer's disease (AD). APOE4 mouse models have provided advances in the …