Alzheimer's disease (AD) represents one of the most common and debilitating
neurodegenerative disorders. By the end of 2040, AD patients might reach 11.2 million in …

With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …

Although the separation of transcription and translation, mediated by the nuclear envelope,
is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic …

Eukaryotic cells possess considerable internal complexity, differentiating them from
prokaryotes. Eukaryogenesis, an evolutionary transitional period culminating in the last …

Embryonic development requires tight control of gene expression levels, activity, and
localisation. This control is coordinated by multiple levels of regulation on DNA, RNA and …

In this hypothesis article, we explore the origin of the eukaryotic nucleus. In doing so, we first
look afresh at the nature of this defining feature of the eukaryotic cell and its core functions …

The nuclear pore complex (NPC) regulates the selective transport of large biomolecules
through the nuclear envelope. As a model system for nuclear transport, we construct NPC …

The telomerase ribonucleoprotein particle (RNP) replenishes telomeric DNA and minimally
requires an RNA component and a catalytic protein subunit. However, telomerase RNP …

Influenza A virus (IAV) is the primary causative agent of influenza, colloquially called the flu.
Each year, it infects up to a billion people, resulting in hundreds of thousands of human …

After many decades, during which most molecular studies on the regulation of gene
expression focused on transcriptional events, it was realized that post-transcriptional control …