The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …
Diverse biological functions of the renin‐angiotensin system
The renin‐angiotensin system (RAS) has been widely known as a circulating endocrine
system involved in the control of blood pressure. However, components of RAS have been …
system involved in the control of blood pressure. However, components of RAS have been …
[HTML][HTML] Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches
OS Mohammed, HG Attia… - … of Pharmacy & …, 2023 - frontierspartnerships.org
Long-term liver injuries lead to hepatic fibrosis, often progressing into cirrhosis, liver failure,
portal hypertension, and hepatocellular carcinoma. There is currently no effective therapy …
portal hypertension, and hepatocellular carcinoma. There is currently no effective therapy …
Pharmacological therapy of metabolic dysfunction-associated steatotic liver disease-driven hepatocellular carcinoma
Y Wang, JS Fleishman, T Li, Y Li, Z Ren… - Frontiers in …, 2024 - frontiersin.org
In light of a global rise in the number of patients with type 2 diabetes mellitus (T2DM) and
obesity, non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction …
obesity, non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction …
The repurposing of non-peptide neurokinin-1 receptor antagonists as antitumor drugs: An urgent challenge for aprepitant
R Coveñas, FD Rodríguez, P Robinson… - International journal of …, 2023 - mdpi.com
The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer
progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration …
progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration …
[HTML][HTML] State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy
X Zhong, M Lv, MQ Ma, Q Huang, R Hu, J Li, J Yi… - Biomedicine & …, 2023 - Elsevier
With the obesity epidemic, nonalcoholic steatohepatitis (NASH) is emerging as the fastest
growing potential cause of hepatocellular carcinoma (HCC). NASH has been demonstrated …
growing potential cause of hepatocellular carcinoma (HCC). NASH has been demonstrated …
Role of peritumoral tissue analysis in predicting characteristics of hepatocellular carcinoma using ultrasound-based radiomics
H Qian, Y Huang, L Xu, H Fu, B Lu - Scientific Reports, 2024 - nature.com
Predicting the biological characteristics of hepatocellular carcinoma (HCC) is essential for
personalized treatment. This study explored the role of ultrasound-based radiomics of …
personalized treatment. This study explored the role of ultrasound-based radiomics of …
[HTML][HTML] Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis: Should we consider further implications?
M Barone - World Journal of Gastroenterology, 2024 - ncbi.nlm.nih.gov
This editorial contains comments on the article by Zhao et al in print in the World Journal of
Gastroenterology. The mechanisms responsible for hepatic fibrosis are also involved in …
Gastroenterology. The mechanisms responsible for hepatic fibrosis are also involved in …
Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine
S Zheng, C Xue, S Li, X Zao, X Li, Q Liu… - Frontiers in …, 2024 - frontiersin.org
Liver cirrhosis arises from liver fibrosis and necroinflammation caused by various
mechanisms of hepatic injury. It is a prevalent condition in clinical practice characterized by …
mechanisms of hepatic injury. It is a prevalent condition in clinical practice characterized by …
Concomitant use of renin-angiotensin system inhibitors augments the efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis
J Yu, F Meng, W Sui, J Yu, J Shen - Frontiers in Pharmacology, 2024 - frontiersin.org
Background The impact of renin-angiotensin system inhibitors (RASIs) on the outcome of
hypertensive cancer patients undergoing immune checkpoint inhibitor (ICIs) therapy …
hypertensive cancer patients undergoing immune checkpoint inhibitor (ICIs) therapy …