Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …

Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast
cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted …

Abstract The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival
against stressors, including heat, in both healthy and cancer cells. Modulated electro …

Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients
often respond to EGFR tyrosine kinase inhibitors (TKIs) initially but eventually develop …

Simple Summary Heat shock factor 1 (HSF1) is a transcription factor crucial for cellular
stress responses. HSF1 activates heat shock proteins (HSPs) in response to proteotoxic …

Cells undergo numerous processes to adapt to new challenging conditions and stressors.
Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock …

Background Advanced lung adenocarcinoma patients often develop resistance to EGFR
tyrosine kinase inhibitors (EGFR-TKIs), leaving uncertainties regarding subsequent …

Microglia are key components of the central innate immune system. The over-activation of
microglia, which occurs in nervous system disorders, is usually accompanied with …