Genomics-based precision medicine has revolutionized oncology but also has inherent
limitations. Functional precision oncology is emerging as a complementary approach that …

Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal
malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and …

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …

CRISPR/Cas13a is a powerful genome editing system for RNA knockdown that holds
enormous potential for cancer treatment by targeting currently undruggable oncogenes or …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

Metastatic colorectal cancer (CRC) is a common cause of cancer-related mortality, of which
peritoneal metastases (PMs) have the worse outcome. Metastasis-specific markers may help …

A proportion of gastric cancer (GC) patients suffer from peritoneal metastasis (PM) in the late
stage of tumor and these patients have a poor prognosis. To provide more care for GC …

Background Patients with colorectal peritoneal metastases who are not eligible for
cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) owing …

Background Selected patients with peritoneal metastases of colorectal cancer (PM-CRC)
can benefit from potentially curative cytoreductive surgery (CRS)±hyperthermic …

Background Colorectal cancer (CRC) can be divided into four consensus molecular
subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial …