Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the
azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

The cytochromes P450 (P450s) are probably nature's most versatile enzymes in terms of
both their vast substrate range and the diverse types of molecular transformations performed …

Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in
almost all organisms. CYPs share a common protein fold but differ in substrate selectivity …

Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …

Cytochrome P450 3A4 (CYP3A4) is the most abundant membrane-associated isoform of the
P450 family in humans and is responsible for biotransformation of more than 50% of drugs …

Cytochrome P450 (CYP) enzymes play crucial roles during the evolution and diversification
of ancestral monocellular eukaryotes into multicellular eukaryotic organisms due to their …

Recombinant expression of membrane-bound cytochrome P450s in bacterial expression
systems provide a well-established system capable of producing large yields of catalytically …