Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …

Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated
in regulating stress responses to oxidative damage and cell death, which are closely related …

Cuproptosis is a recently recognized modality of cell death driven by intracellular copper-
dependent mitochondrial stress. However, the mediators of the sterile inflammatory …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

In the early 1970s, a group of non-histone nuclear proteins with high electrophoretic mobility
was discovered and named high-mobility group (HMG) proteins. High-mobility group box 1 …

Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Aberrant innate immunity in the brain has been implicated in the pathogenesis of several
central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's …

Hyperinflammation characterized by elevated proinflammatory cytokines known as 'cytokine
storms' is the major cause of high severity and mortality seen in COVID‐19 patients. The …

Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and
inflammation contributes substantially to its occurrence and progression. The prevalence of …