Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its
efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) …

A subset of children with autism spectrum disorder appear to show an improvement in their
behavioural symptoms during the course of a fever, a sign of systemic inflammation,. Here …

Mouse models of neuropsychiatric diseases provide a platform for mechanistic
understanding and development of new therapies. We previously demonstrated that …

Environmental challenges to the maternal immune system during pregnancy have been
associated with an increase in the frequency of neurodevelopmental disorders such as …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

The increasing prevalence of neurodevelopmental disorders, especially autism spectrum
disorders (ASD) and attention deficit hyperactivity disorder (ADHD), calls for more research …

Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …