Physiology of pregnancy and oral local anesthesia considerations

X Zhou, Y Zhong, Z Pan, J Zhang, J Pan - PeerJ, 2023 - peerj.com
Background Safe and effective local anesthesia is a prerequisite for emergency oral
surgeries and most dental treatments. Pregnancy is characterized by complex physiological …

Clinical guidance for unfractionated heparin dosing and monitoring in critically ill patients

MN Samimi, A Hale, J Schults, A Fischer… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Unfractionated heparin is a widely used anticoagulant in critically ill patients. It
has a well-established safety profile and remains an attractive option for clinicians due to its …

Pharmacokinetic characterisation of a valproate Autism Spectrum Disorder rat model in a context of co-exposure to α-Hexabromocyclododecane

C Morel, J Paoli, C Emond, F Debaugnies… - Environmental …, 2024 - Elsevier
Assessing the role of α-hexabromocyclododecane α-HBCDD as a factor of susceptibility for
Autism Spectrum disorders by using valproic acid-exposed rat model (VPA) required …

Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides

A Weyrich, M Joel, G Lewin, T Hofmann… - Birth Defects …, 2022 - Wiley Online Library
Background In silico methods for toxicity prediction have increased significantly in recent
years due to the 3Rs principle. This also applies to predicting reproductive toxicology, which …

Drug-related problems in hypertension and gestational diabetes mellitus: A hospital cohort

PK Vale Bezerra, JE Chaves Cavalcanti… - Plos one, 2023 - journals.plos.org
Objective To characterize the drug-related problems (DRPs) in high-risk pregnant women
with hypertension and gestational diabetes mellitus according to frequency, type, cause, and …

Signal mining of adverse reactions in the antiemetic drug ondansetron during pregnancy: A Real-World analysis of the FDA adverse Event Reporting System (FAERS)

T Chen, C Chen, H Zhou, J Zhang - Expert Opinion on Drug Safety, 2024 - Taylor & Francis
Background The aim of this study is to assess the risks associated with the use of
ondansetron in pregnant women in real-world based on the Food and Drug Administration …

Two successful pregnancies‐in patients taking Volanesorsen for familial chylomicronemia syndrome

S Wanninayake, A Ochoa‐Ferraro, K Patel… - JIMD …, 2024 - Wiley Online Library
Familial chylomicronemia syndrome (FCS) is a rare inherited disorder characterized by
severe hypertriglyceridemia, posing a heightened risk of acute pancreatitis. Recently …

Design Considerations for Pharmacokinetic Studies During Pregnancy

CS Stika, MF Hebert - The Journal of Clinical Pharmacology, 2023 - Wiley Online Library
Most of the interventions performed by obstetric providers involve the administration of
drugs. Pregnant patients are pharmacologically and physiologically different from …

Diagnosis and Treatment of Women with Epilepsy

Z Chen, X Geng, Y Li, L Sha, Y Fu, L Chen… - Women with Epilepsy in …, 2024 - Springer
The correct diagnosis of epilepsy has important guiding significance for the choice of
treatment and prognosis of epilepsy. About 30% of patients with epilepsy develop drug …

[HTML][HTML] Strategies to Reduce Harm Through Clinical Research

A March, A Helman, MF Riley… - … with Pregnant and …, 2024 - ncbi.nlm.nih.gov
The most straightforward way to mitigate liability is to prevent harm in the first place. While it
is impossible to eliminate any possibility of injury during clinical research, and therefore …