Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Despite numerous attempts over many years to develop an HIV vaccine based on classical
strategies, none has convincingly succeeded to date. A number of approaches are being …

Broadly neutralizing antibodies against highly variable viral pathogens are much sought
after to treat or protect against global circulating viruses. Here we probed the neutralizing …

Despite tremendous efforts, development of an effective vaccine against human
immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous …

Influenza virus infection is an ongoing health and economic burden causing epidemics with
pandemic potential, affecting 5–30% of the global population annually, and is responsible …

The rapid dissemination of the 2009 pandemic influenza virus underscores the need for
universal influenza vaccines that elicit protective immunity to diverse viral strains. Here, we …

More than 25 years have passed since the discovery of HIV type 1, the causative agent of
AIDS, and the first vaccine candidate to exhibit evidence for protection against infection was …

Licensed vaccines against viral diseases generate antibodies that neutralize the infecting
virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 …

Respiratory syncytial virus (RSV) is an important cause of respiratory disease causing high
rates of hospitalizations in infants, significant morbidity in children and adults, and excess …

Current influenza virus vaccines protect mostly against homologous virus strains; thus,
regular immunization with updated vaccine formulations is necessary to guard against the …