Propofol is an intravenous hypnotic drug that is used for induction and maintenance of
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …

Automation empowers self-sustainable adaptive processes and personalized services in
many industries. The implementation of the integrated healthcare paradigm built on Health …

Dexmedetomidine can be used for sedation and analgesia and has been approved for this
use by the European Medicines Agency since 2017. It causes an arousable state of …

Safe anesthesia is achieved using objective methods that estimate the patient's state during
different phases of surgery. A patient's state under anesthesia is characterized by three …

Inadequate pain and/or stress management in preterm‐and term‐born infants has been
associated with increased morbidity and even mortality. However, exposure to …

Theranostic imaging methods could greatly enhance our understanding of the distribution of
CNS-acting drugs in individual patients. Fluorine-19 magnetic resonance imaging (19 F …

The major therapeutic end points of general anesthesia include hypnosis, amnesia, and
immobility. There is a complex relationship between general anesthesia, responsiveness …

In this paper, a reinforcement learning (RL)-based optimal adaptive control approach is
proposed for the continuous infusion of a sedative drug to maintain a required level of …

Hospitalized pediatric patients and those with complex or chronic conditions treated on an
outpatient basis are commonly prescribed multiple drugs, resulting in increased risk for drug …

The failure of preclinical research to advance successful candidate medications in
psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria …