Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …

Introduction Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are
associated with increased mortality, long-term cognitive impairment, and focal neurological …

Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Background The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome
has been identified as an important mediator of blood–brain-barrier disruption in sepsis …

The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐
inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects …

Extracellular vesicles (EVs) have been identified as novel mediators of intercellular
communication. They work via delivering the sequestered cargo to cells in the close vicinity …

Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of
note is that majority of patients have experienced a severe immune depression during and …

Background Owing to metabolic disequilibrium and immune suppression, intracerebral
hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of …