Innate lymphoid cells and cancer: Role in tumor progression and inhibition

X Yuan, F Rasul, B Nashan… - European journal of …, 2021 - Wiley Online Library
Innate lymphoid cells (ILCs), a critical component of the immune system, have recently been
nominated as emerging players associated with tumor progression and inhibition. ILCs are …

[HTML][HTML] Cancer immunotherapy by blocking immune checkpoints on innate lymphocytes

S Pesce, S Trabanelli, C Di Vito, M Greppi, V Obino… - Cancers, 2020 - mdpi.com
Simple Summary The emergence of immunotherapy for cancer treatment bears
considerable clinical promise. The role of NK cells in tumor immunosurveillance and their …

[HTML][HTML] Nitric oxide-mediated enhancement and reversal of resistance of anticancer therapies

E Hays, B Bonavida - Antioxidants, 2019 - mdpi.com
In the last decade, immune therapies against human cancers have emerged as a very
effective therapeutic strategy in the treatment of various cancers, some of which are resistant …

Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes

L Rethacker, M Boy, V Bisio, F Roussin… - …, 2022 - Taylor & Francis
Innate lymphoid cells (ILCs)–which include cytotoxic Natural Killer (NK) cells and helper-
type ILC–are important regulators of tissue immune homeostasis, with possible roles in …

[HTML][HTML] Cutaneous squamous cell carcinoma development is associated with a temporal infiltration of ILC1 and NK cells with immune dysfunctions

C Luci, F Bihl, P Bourdely, S Khou, A Popa… - Journal of Investigative …, 2021 - Elsevier
NK cells and tissue-resident innate lymphoid cells (ILCs) are innate effectors found in the
skin. To investigate their temporal dynamics and specific functions throughout the …

[HTML][HTML] Therapeutic manipulation of innate lymphoid cells

LM Cobb, MR Verneris - JCI insight, 2021 - ncbi.nlm.nih.gov
Since their relatively recent discovery, innate lymphoid cells (ILCs) have been shown to be
tissue-resident lymphocytes that are critical mediators of tissue homeostasis, regeneration …

[HTML][HTML] Resisting resistance to immune checkpoint therapy: a systematic review

Y Haibe, Z El Husseini, R El Sayed… - International Journal of …, 2020 - mdpi.com
The treatment landscape in oncology has witnessed a major revolution with the introduction
of checkpoint inhibitors: anti-PD1, anti-PDL1 and anti-CTLA-4. These agents enhance the …

[HTML][HTML] Pleiotropic role and bidirectional immunomodulation of innate lymphoid cells in cancer

Z An, F Flores-Borja, S Irshad, J Deng, T Ng - Frontiers in immunology, 2020 - frontiersin.org
Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the
environmental signals from surrounding tissues and other immune cells. The pleiotropic …

Multidimensional molecular controls defining NK/ILC1 identity in cancers

A Crinier, Y Kerdiles, M Vienne, B Cózar, E Vivier… - Seminars in …, 2021 - Elsevier
Abstract Innate Lymphoid Cells (ILCs) are a recently described heterogeneous population of
non-T, non-B lymphocytes. They are highly abundant at mucosal interfaces and, unlike T …

Advances in immunotherapy for pancreatic ductal adenocarcinoma

M Miyazawa, M Katsuda, M Kawai… - Journal of Hepato …, 2021 - Wiley Online Library
Advances in immunotherapy against advanced cancers can be considered stunning and
epoch‐making. Meanwhile, efficacy of immune‐based therapies, especially immune …