Malignant mesothelioma: global incidence and relationship with asbestos

C Bianchi, T Bianchi - Industrial health, 2007 - jstage.jst.go.jp
Mesothelioma incidence varies markedly from one country to another. The highest annual
crude incidence rates (about 30 cases per million) are observed in Australia, Belgium, and …

A scoping review to identify strategies that work to prevent four important occupational diseases

AR Keefe, PA Demers, B Neis… - American Journal of …, 2020 - Wiley Online Library
Background Despite being largely preventable, many occupational diseases continue to be
highly prevalent and extremely costly. Effective strategies are required to reduce their …

Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings

T Vierikko, R Järvenpää, T Autti, P Oksa… - European …, 2007 - Eur Respiratory Soc
The objective of the present study is to determine the feasibility of chest computed
tomography (CT) in screening for lung cancer among asbestos-exposed workers. In total …

[HTML][HTML] Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma

M Yin, M Tissari, J Tamminen, I Ylivinkka, M Rönty… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Malignant mesothelioma originates from mesothelial cells and is a cancer type that
aggressively invades into the surrounding tissue, has poor prognosis and no effective …

[HTML][HTML] Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

JA Tamminen, V Parviainen, M Rönty, AP Wohl… - Oncogenesis, 2013 - nature.com
Malignant mesothelioma is a form of cancer that is highly resistant to conventional cancer
therapy for which no major therapeutic advances have been introduced. Here, we identify …

[HTML][HTML] Overexpression of activin-A and-B in malignant mesothelioma–Attenuated Smad3 signaling responses and ERK activation promote cell migration and …

JA Tamminen, M Yin, M Rönty, E Sutinen… - Experimental cell …, 2015 - Elsevier
Activin-A and activin-B, members of the TGF-β superfamily, are regulators of reproductive
functions, inflammation and wound healing. These dimeric molecules regulate various …

Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos

B Pesch, D Taeger, G Johnen, IM Gross… - International journal of …, 2010 - Elsevier
The objective of this analysis was the estimation of the cancer risks of asbestos and
asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 …

Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk

M Amati, M Tomasetti, L Mariotti, LM Tarquini… - … /Genetic Toxicology and …, 2008 - Elsevier
Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and
lung cancer have increased with increasing cumulative exposure to asbestos. To investigate …

Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling

JA Tamminen, M Myllärniemi… - Journal of Cellular …, 2012 - Wiley Online Library
The inhalation of asbestos fibers is considered to be highly harmful, and lead to fibrotic
and/or malignant disease. Epithelial‐to‐mesenchymal transition (EMT) is a common …

Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer

E Kettunen, K Salmenkivi, K Vuopala, T Toljamo… - Lung Cancer, 2006 - Elsevier
Lung cancer specimens display recurrent copy number aberrations in distinguished
chromosomal regions as compared with normal lung cells. Such alterations have been …