Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

Human stem cell derived brain organoids are increasingly gaining attention as an ideal
model system for investigating neurological diseases, particularly those that involve …

Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are
neurodegenerative diseases with overlapping clinical phenotypes based on impaired …

Amyotrophic lateral sclerosis is a rare and fatal neurodegenerative disease characterised by
progressive deterioration of upper and lower motor neurons that eventually culminates in …

Autophagy is an intracellular recycling and degradation pathway that depends on
membrane trafficking. Rab GTPases are central for autophagy but their regulation especially …

Cannabinoids are the major chemical constituents of the plant Cannabis sativa L. and are
known to exhibit a wide range of pharmacological effects viz., psychotropic, analgesic …

Ex vivo gene therapy involves the genetic modification of cells outside of the body to
produce therapeutic factors and their subsequent transplantation back into patients. Various …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a
predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream …

Amyotrophic lateral sclerosis is a pernicious neurodegenerative disorder that is associated
with the progressive degeneration of motor neurons, the disruption of impulse transmission …