The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

Early and accurate diagnosis of Creutzfeldt–Jakob disease (CJD) is a necessary to
distinguish this untreatable disease from treatable rapidly progressive dementias, and to …

Melatonin suppresses tumor development. However, the exact relationship between
melatonin and cancer stem cells (CSC s) is poorly understood. This study found that …

Brucella abortus is a Gram-negative bacterium causing brucellosis. Although B. abortus is
known to infect via the oral route, the entry site in the gastrointestinal tract has been unclear …

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal
neurodegenerative disorders in mammals that are caused by unconventional agents …

Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia
and surgery in elderly patients. While often reversible, it consumes medical resources …

Alzheimer's disease is associated with the accumulation within the brain of amyloid-β (Aβ)
peptides that damage synapses and affect memory acquisition. This process can be …

Prion protein has two isoforms including cellular prion protein (PrPC) and scrapie prion
protein (PrPSc). PrPSc is the pathological aggregated form of prion protein and it plays an …

Cellular prion protein (PrPC) is a highly conserved glycoprotein, present both anchored in
the cell membrane and soluble in the extracellular medium. It has a diversity of ligands and …

The co-chaperone stress-inducible protein 1 (STI1) is released by astrocytes, and has
important neurotrophic properties upon binding to prion protein (PrP C). However, STI1 …