Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes
termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set …

Bladder cancer is a heterogeneous group of tumours with at least 40 histological subgroups.
Patients with localized disease can be cured with surgical resection or radiotherapy, but …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

MicroRNAs (miRNAs) are small RNAs that function as posttranscriptional regulators of gene
expression. miRNAs affect a variety of signaling pathways, and impaired miRNA regulation …

The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn
inhibits cell proliferation and growth through induction of specific target genes. Cell growth is …

The mammalian target of rapamycin (mTOR) regulates cell growth and survival by
integrating nutrient and hormonal signals. These signaling functions are distributed between …

Converging signals from the mammalian target of rapamycin (mTOR) and phosphoinositide
3-kinase (PI3K) pathways are well established to modulate translation initiation. Less is …

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and
metabolism with environmental inputs to ensure that cells grow only under favourable …

Adiponectin is an adipose tissue–secreted endogenous insulin sensitizer, which plays a key
role as a mediator of peroxisome proliferator-activated receptor γ action. Adiponectin alters …