Objective We investigated genome-wide changes in gene expression and chromatin
remodelling induced by tumour necrosis factor (TNF) in fibroblast-like synoviocytes (FLS) …

Immunological tolerance loss is fundamental to the development of autoimmunity; however,
the underlying mechanisms remain elusive. Immune tolerance consists of central and …

Epigenetic modifications can stably alter gene expression and have been shown to be
important in the maintenance of cell type-specific functions as well as in cell differentiation …

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by destructive
hyperplasia of the synovium. Fibroblast‐like synoviocytes (FLS) are a major component of …

Age is the most important risk factor for the development of infectious diseases, cancer and
chronic inflammatory diseases including rheumatoid arthritis (RA). The very act of living …

Rheumatoid arthritis (RA) is the most common autoimmune articular disorder. It is
characterized by chronic inflammation and progressive joint destruction. As research …

The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or
glycation of cellular proteins result in the generation and accumulation of advanced …

Fibroblast-like synoviocytes (FLSs) are critical to joint inflammation and destruction in
rheumatoid arthritis (RA). Increased glycolysis in RA FLSs contributes to persistent joint …

Epigenetic anomalies are emerging as key pathogenic features of rheumatoid arthritis (RA).
The effect of epigenetics in RA ranges from contributing to complex disease mechanisms to …

Objectives To study the expression, regulation and function of the histone methyltransferase
enhancer of zeste homologue 2 (EZH2) in synovial fibroblasts (SF) from patients with …