Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T cell
overactivation and B cell hyper-stimulation. Hematopoietic progenitor kinase 1 (HPK1, also …

Epigenetic changes are of crucial importance in the etiopathogenesis of autoimmune liver
diseases. Among these, there is limited agreement on the definitions and treatment of …

Monozygotic twins share an identical DNA sequence but are not truly “identical”. In fact,
when it comes to health and disease, they may often display some level of phenotypic …

The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) is a critical factor
of cartilage destruction in rheumatoid arthritis (RA). Increased FLSs migration and …

Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation
of the joints with severe pain and swelling, joint damage and disability, which leads to joint …

In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium
tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease …

The relationships between immunological dysfunction, loss of tolerance and hematologic
malignancies have been a focus of attention in attempts to understand the appearance of a …

Objective. Vitamin D (VitD) has immunomodulatory activity relevant to rheumatoid arthritis
(RA) and acts by binding nuclear receptors that regulate gene transcription. VitD receptor …

Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation
and progressive destruction of cartilage and bone which leads to ultimately loss of function …

Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of
host defenses that can lead to a more prominent immune response and shape the course of …