The concept of “trained innate immunity” is understood as the ability of innate immune cells
to remember invading agents and to respond nonspecifically to reinfection with increased …

Simple Summary Multiple myeloma is a cancer of plasma cells causing bone fractures,
anemia, renal insufficiency and hypercalcemia. Despite the introduction of new drugs in the …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Synovial fibroblasts are recognized as key cells in the pathogenesis of RA since they attract …

Epigenetics is the study of nucleotide modifications that are heritable and act as regulatory
mechanisms without changing the nucleotide sequence of the genome. Exogenous cues …

Bone remodeling is a complex event that maintains bone homeostasis. The epigenetic
mechanism of the regulation of bone remodeling has been a major research focus over the …

Objective Based on previous data that have linked the small ubiquitin-like modifier-1 (SUMO-
1) to the pathogenesis of rheumatoid arthritis (RA), we have investigated the expression of …

Rheumatoid arthritis (RA) is a complex disease affecting approximately 0.5–1% of the
population. While there are effective biologic therapies, in up to 40% of patients, disease …

Background: The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases
that play a variety of physiological and pathological roles in development, remodeling of …

Growing evidence supports the idea that aberrancies in epigenetic processes contribute to
the onset and progression of human immune-mediated inflammatory diseases, such as …

Epigenetics is a steadily growing research area in many human diseases, especially in
autoimmune diseases such as rheumatoid arthritis (RA). RA is an autoimmune disease with …