Dynamic modification involving small ubiquitin-like modifier (SUMO) has emerged as a new
mechanism of protein regulation in mammalian biology. Sumoylation is an ATP-dependent …

Objective Arthritis is a chronic inflammatory disease characterised by immune cell infiltration
and mesenchymal cell expansion in the joints. Although the role of immune cells in arthritis …

Abstract Aberrant matrix metalloproteinase-1 (MMP-1) expression contributes to the
pathogenesis of many degenerative disease processes that are associated with increased …

The aim of the present study was to identify differentially expressed genes (DEGs) between
individuals with rheumatoid arthritis (RA) and healthy controls, in order to provide a …

Abstract According to the World Health Organization, chronic diseases account for an
estimated 35 million deaths per year, representing∼ 60% of worldwide mortality. 163 These …

目的: 研究金雀异黄素(genistein, Gen) 对I 型胶原诱导型关节炎(type I collagen-induced
arthritis, CIA) 大鼠关节滑膜血管新生的影响. 方法: 将40 只大鼠随机分为空白对照组 …

Rheumatic disease is a large spectrum of heterogeneous conditions affecting the loco-motor
system including joints, muscles, connective tissues, and soft tissues around the joints and …

Small ubiquitin-like modifier (SUMO) proteins can reversibly attach covalently or non-
covalently to lysine residues of various substrates. The processes are named SUMOylation …

Several crucial issues remain open in our understanding of primary biliary cirrhosis (PBC),
an autoimmune liver disease targeting the small-and medium-sized intrahepatic bile ducts …

The association of rheumatoid arthritis (RA) with a number of genetic risk loci is well
established; however, only part of the risk to develop the disease is based on genetics …