Epigenetics encompass all inheritable, although potentially reversible changes in the
genome, that do not alter the DNA code, but result from both developmentally (ensuring …

Epigenetics as the science about inheritables modifications of genetic information without
DNA sequence changes, is atracting an increasing focus among scientific community, for his …

Objectives: Epigenetic modifications play an important role in the regulation of gene
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …

Rheumatoid arthritis, immunosenescence and the hallmarks of aging Page 16 Chapter 4 15
Chapter 2 Rheumatoid arthritis, immunosenescence and the hallmarks of aging Current …

Epigenetic mechanisms, including DNA methylation and histone modifications, account for a
highly sophisticated regulatory system that is fundamental to the regulation of many cellular …

Rheumatoid arthritis (RA) is a common autoimmune disorder which shows clinical
heterogeneity. It has multiple treatment options, and there is individual variation in response …

The myeloid cell lineage is a fundamental element of the immune system and it can give rise
to a diverse set of terminally differentiated cells, such as macrophages or osteoclasts among …

Tuberculosis (TB) continues to kill globally and this is compounded by increasing drug-
resistance. Neutrophil influx and tissue destruction are hallmarks of TB and this is …

OBJECTIVE: Based on previous data that have linked the small ubiquitin-like modifier-1
(SUMO-1) to the pathogenesis of rheumatoid arthritis (RA), we have investigated the …

The fast technological progress of bio-medical research in the last decade led to the
accumulation of vast amounts of data and opened new fields of research, such as …