Insulin resistance (IR) is a pathological condition strongly associated with obesity. However,
corticosteroids or growth hormone therapy and genetic diseases may affect insulin …

The pathophysiology of diabetes as a disease is characterised by an inability to maintain
normal glucose homeostasis. In type 1 diabetes, this is due to autoimmune destruction of the …

Background and Aims Although the majority of patients with non-alcoholic fatty liver disease
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic …

Objective The present study aimed to validate homeostasis model assessment of insulin
resistance (HOMA-IR) in relation to the insulin tolerance test (ITT) in a model of insulin …

The objective of this study was to determine the optimal conditions under which to assess
glucose tolerance in chow-and high-fat-fed C57BL/6J mice. Mice were fed either chow or …

Obesity has reached epidemic proportions worldwide and reports estimate that American
children consume up to 25% of calories from snacks. Several animal models of obesity exist …

Background The incidence of the insulin resistance syndrome has increased at an alarming
rate worldwide, creating a serious challenge to public health care in the 21st century …

Autophagy is essential for maintaining both survival and health of cells. Autophagy is
normally suppressed by amino acids and insulin. It is unclear what happens to the …

Insulin resistance plays a role in the pathogenesis of diabetes, including gestational
diabetes. The glucose clamp is considered the gold standard for determining in vivo insulin …

The manner by which genotype and environment affect complex phenotypes is one of the
fundamental questions in biology. In this study, we quantified the transcriptome—a subset of …