Conventionally, drug development has spanned three distinct phases, and the success rate
for experimental drugs across phases has been less than 15%(Hay, Thomas, Craighead …

Purpose To facilitate decision making in the oncology clinic, technologies have recently
been developed to independently inject and assess multiple anticancer agents directly in a …

The complexity of tumor immunobiology urges for multimodal immunotherapeutic
approaches. Therefore, in this thesis, a combination of tumor vaccination, interleukin-12 (IL …

The alkaline earth metals in the periodic table contain a series of elements including calcium
(Ca), strontium (Sr), barium (Ba), and radium (Ra)(see Fig. 11.1). Each of these compounds …

Prostate cancer is a bone-metastatic disease but until recently bone-targeted therapies had
never demonstrated improvements in survival. Prior radiopharmaceuticals have …

This chapter provides an overview of Bayesian concepts and methods for design and
conduct of clinical trials of treatment regimens, including targeted agents. A targeted …

In the past 3 years, we have witnessed the completion of four randomized phase III studies
in neuroendocrine tumors and the approval of two new drugs, everolimus and sunitinib, for …

Statement of the problem:-The primary objective of this thesis was to determine the best
study design to evaluate the safety and effectiveness of an intermediate dose of low …

Sie zeigen Zweierlei: 1. Dezentralisierung ist nachteilig, einzelne Alleskönner sind teuer,
wirtschaftlich ineffizient. Spezifizierung und ein gewisses Maß an Zentralisierung sind …

Sie zeigen Zweierlei: 1. Dezentralisierung ist nachteilig, einzelne Alleskönner sind teuer,
wirtschaftlich ineffizient. Spezifizierung und ein gewisses Maß an Zentralisierung sind …