Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of
methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME) …

The prevention and treatment of postmenopausal osteoporosis (PMOP) is a significant
public health issue, and non-coding RNAs are of vital importance in this process. In this …

Molecular diagnostic testing of the 11p15. 5-associated imprinting disorders Silver-Russell
and Beckwith-Wiedemann syndrome (SRS, BWS) is challenging due to the broad spectrum …

Long noncoding RNAs (lncRNAs) are implicated in a number of regulatory functions in
eukaryotic genomes. In humans, KCNQ1OT1 is a 91 kb imprinted lncRNA that inhibits …

Background Imprinting centre 2 (IC2) in the chromosomal region 11p15. 5 regulates the
monoallelic expression of imprinted genes by differential methylation of paternal and …

罕见病Beckwith⁃Wiedemann综合征1例病例报告 Page 1 基金项目中国科学技术大学附属第一
医院(安徽省立医院)创新项目:MAI2022C008;安徽省自然科学基金面上项目:1608085MH196 …

In this brief communication, we address the possible associations of a 132 bp deletion within
the antisense gene KCNQ1OT1 on 11p15. 5 to growth abnormalities. We question its …

Abstract The Silver–Russell syndrome (SRS) is a rare disorder characterized by
heterogeneous clinical features, including growth retardation, typical facial dysmorphisms …

Background Two imprinting control centres, H19/IGF2: IG-differentialy methylated region
(DMR) and KCNQ1OT1: TSS-DMR, reside on chromosome 11p15. 5. Paternal deletions …

In the articles linked to this commentary and also published by the Journal of Medical
Genetics, two groups independently report on the same small deletion in 11p15. 5 which …