Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and
regulates cardiac function through both vascular-dependent and-independent effects. The …

Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces
positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we …

The parasympathetic component of the autonomic nervous system plays an important role in
the physiological regulation of cardiac function by exerting significant influence over the …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Excitation–contraction (EC) coupling is driven by an ion-channel-mediated calcium cycle
that produces myofilament contraction and relaxation. Even though nitric oxide synthases …

The mechanisms by which nitric oxide (NO) influences myocardial Ca2+ cycling remain
controversial. Because NO synthases (NOS) have specific spatial localization in cardiac …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

To study the role of cGMP-dependent protein kinase I (cGKI) for cardiac contractility, force of
contraction (Fc) was studied in electrically driven heart muscle from wild-type (WT) mice and …

Calmodulin is the primary sensor of intracellular calcium (Ca2+) levels in eukaryotic cells
playing a key role in the proper deciphering of Ca2+ signalling. Given the versatility of Ca2+ …