Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

In recent years, the activation of unactivated alkyl chlorides through light-induced processes
has emerged as a promising field in radical chemistry, and has led to new transformations in …

Although flavin-dependent halogenases (FDHs) are attractive for C–H bond activation, their
applications are limited due to low turnover and stability. We have previously shown that …

Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

Enzymes are nature's catalysts that are designed to accelerate specific reactions up to 106
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …