Melanoma is an extremely aggressive tumor and is considered to be an extremely
immunogenic tumor because compared to other cancers it usually presents a well …

The role of neoadjuvant therapy is undergoing an historic shift in oncology. The emergence
of potent immunostimulatory anticancer agents has transformed neoadjuvant therapy from a …

Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in
adults and is highly metastatic, resulting in a poor patient prognosis. Sphingolipid …

Analyzing antigen-specific T cell responses at scale has been challenging. Here, we
analyze three types of T cell receptor (TCR) repertoire data (antigen-specific TCRs, TCR …

Background Uveal melanoma (UM) is the most common intraocular malignancy in adults. In
contrast to cutaneous melanoma (CM), there is no standard therapy, and the efficacy and …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Therapeutic resistance to immune checkpoint blockers (ICBs) in melanoma patients is a
pressing issue, of which tumor loss of IFN-γ signaling genes is a major underlying …

Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the
liver. Despite the identification of the early driver mutations during the development of the …

Tumor-specific neoepitopes are promising targets in cancer immunotherapy. However, the
identification of functional tumor-specific neoepitopes remains challenging. In addition to the …

Although melanoma is one of the most immunogenic tumors, it has an ability to evade anti-
tumor immune responses by exploiting tolerance mechanisms, including negative immune …