[HTML][HTML] Malaria in pregnancy

EN Takem, U D'Alessandro - Mediterranean journal of hematology …, 2013 - ncbi.nlm.nih.gov
Pregnant women have a higher risk of malaria compared to non-pregnant women. This
review provides an update on knowledge acquired since 2000 on P. falciparum and P. vivax …

Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

[HTML][HTML] Pathogenesis of malaria in tissues and blood

B Autino, Y Corbett, F Castelli… - Mediterranean journal of …, 2012 - ncbi.nlm.nih.gov
The clinical manifestations of severe malaria are several and occur in different anatomical
sites. Both parasite-and host-related factors contribute to the pathogenicity of the severe …

Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae

E Gómez-Díaz, RS Yerbanga, T Lefèvre, A Cohuet… - Scientific reports, 2017 - nature.com
P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene
families such as the var genes. We have examined changes in transcription and histone …

Old and recent advances in life cycle, pathogenesis, diagnosis, prevention, and treatment of malaria including perspectives in Ethiopia

D Nureye, S Assefa - The Scientific World Journal, 2020 - Wiley Online Library
Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major
public health threat in many countries. This article aims to present different aspects of …

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

JL Guler, DL Freeman, V Ahyong, R Patrapuvich… - PLoS …, 2013 - journals.plos.org
Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment
of new antimalarials and vaccines could benefit from an understanding of early molecular …

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development

ED Benavente, DR Oresegun, PF de Sessions… - Scientific Reports, 2018 - nature.com
Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum
parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite …

High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria

YL Tutterrow, A Salanti, M Avril, JD Smith, IS Pagano… - PLoS …, 2012 - journals.plos.org
VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …

High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …

YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …