The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

Subarachnoid hemorrhage (SAH) is a life‐threatening condition, and although its two main
complications—cerebral vasospasm (CVS)/delayed cerebral ischemia (DCI) and early brain …

Renin is the enzyme which is the rate-limiting step in the formation of the hormone
angiotensin II. Therefore, the regulation of renin secretion is critical in understanding the …

Objectives β-blockers are widely used and effective for treating hypertension, acute
myocardial infarction (MI) and heart failure, but they present side-effects mainly due to …

A major rate-limiting step in the renin–angiotensin–aldosterone system is the release of
active renin from endocrine cells (juxtaglomerular (JG) cells) in the media layer of the …

The renin-angiotensin system (RAS) is a hormonal system that controls body fluid volume,
blood pressure, and cardiovascular function in both health and disease. Various tissues …

Disclosed are antisense oligonucleotide, polynucleotide, and peptide nucleic acid
compounds that speci? cally bind to mammalian mRNA encoding a [31-adrenoceptor …

Activation of the hypoxia‐signalling pathway induced by deletion of the ubiquitin‐ligase von
Hippel–Lindau protein causes an endocrine shift of renin‐producing cells to erythropoietin …

Obstructive sleep apnea is known to be associated with diseases such as hypertension,
metabolic disorder, and cancer. A more controversial and less understood association is that …

Although the cyclic AMP signalling cascade is considered to be the main activator of renin
gene expression in renal juxtaglomerular (JG) cells, the molecular pathways along which …