Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease
L Wang, Y Zhou, D Chen, TH Lee - Frontiers in cell and …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …
Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem–like cell traits in breast cancer
ML Luo, C Gong, CH Chen, DY Lee, H Hu, P Huang… - Cancer research, 2014 - AACR
Breast cancer stem–like cells (BCSC) have been implicated in tumor growth, metastasis,
drug resistance, and relapse but druggable targets in appropriate subsets of this cell …
drug resistance, and relapse but druggable targets in appropriate subsets of this cell …
Development of Pin1 inhibitors and their potential as therapeutic agents
Y Nakatsu, Y Matsunaga, K Ueda… - Current Medicinal …, 2020 - ingentaconnect.com
The prolyl isomerase Pin1 is a unique enzyme, which isomerizes the cis-trans conformation
between pSer/pThr and proline and thereby regulates the function, stability and/or …
between pSer/pThr and proline and thereby regulates the function, stability and/or …
A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways
D Yang, W Luo, J Wang, M Zheng, XH Liao… - Journal of controlled …, 2018 - Elsevier
Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide
largely due to lack of effective targeted drugs to simultaneously block multiple cancer-driving …
largely due to lack of effective targeted drugs to simultaneously block multiple cancer-driving …
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function
CH Chen, CC Chang, TH Lee, ML Luo, P Huang… - Cancer research, 2013 - AACR
The Pin1 prolyl isomerase regulates phosphorylation signaling by controlling protein
conformation after phosphorylation, and its upregulation promotes oncogenesis via acting …
conformation after phosphorylation, and its upregulation promotes oncogenesis via acting …
A functional polymorphism at microRNA-629-binding site in the 3′-untranslated region of NBS1 gene confers an increased risk of lung cancer in …
The genetic variations in NBS1 gene have been reported to be associated with cancer risk.
The polymorphisms in 3′-untranslated region (3′-UTR) of NBS1 might affect gene's …
The polymorphisms in 3′-untranslated region (3′-UTR) of NBS1 might affect gene's …
A genome-wide gene–environment interaction analysis for tobacco smoke and lung cancer susceptibility
Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis.
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …
A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer
B Liu, L Yang, B Huang, M Cheng, H Wang, Y Li… - The American Journal of …, 2012 - cell.com
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) may promote
cancer development and progression by inducing tumorigenesis and drug resistance. To …
cancer development and progression by inducing tumorigenesis and drug resistance. To …
Association between chronic obstructive pulmonary disease and lung cancer: a case-control study in Southern Chinese and a meta-analysis
Background Lung cancer and chronic obstructive pulmonary disease (COPD) share a
common risk factor in cigarette smoking and a large portion of patients with lung cancer …
common risk factor in cigarette smoking and a large portion of patients with lung cancer …
A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese
L Yang, B Liu, B Huang, J Deng, H Li… - Human molecular …, 2013 - academic.oup.com
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been
reported to lose function due to genetic alterations in several cancers. WWOX maps to the …
reported to lose function due to genetic alterations in several cancers. WWOX maps to the …