Accumulative evidences indicated that microRNAs (miRNAs) can function as tumor
suppressors and oncogenes, in which genetic variations are implicated in various cancer …

Background: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is a key regulator
of PTH mRNA stability. Secondary hyperparathyroidism (SHPT), which is characterized by …

Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as
oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer …

Human proto‐oncogene c‐Jun and c‐Fos assemble the activator protein‐1 complex which
is a crucial transcription factor responding to environmental factors and promotes …

Accumulated evidence indicates that rare variants exert a vital role on predisposition and
progression of human diseases, which provides neoteric insights into disease etiology. In …

Pin1 is the only known cis-to-trans isomerase that recognizes the phosphorylated pThr/pSer-
Pro motifs in many signaling molecules, playing unique roles in the pathogenesis of breast …

Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1), which regulates the
conformation of Pro-directed phosphorylation sites, has been identified as a critical catalyst …

Mitogen/extracellular signal-regulated kinase-5 (MEK5)/extracellular signal-regulated
protein kinase-5 (ERK5) pathway plays a pro-oncogenic role in tumourigenesis by anticell …

Signal‐induced proliferation associated gene 1 (Sipa1) is a signal transducer to activate the
Ras‐related proteins and modulate cell progression, differentiation, adhesion and cancer …

Essential hypertension is a major risk factor for cardiovascular morbidity and mortality, and
the early-diagnosis is very important for the prevention of essential hypertension. Previously …