Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

Tissue-resident macrophages have been associated with important and diverse biological
processes such as native immunity, tissue homeostasis and angiogenesis during …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which
invade the developing embryo and persist by means of local self-renewal. However, the …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Hematopoietic stem cells (HSCs) in adults are believed to be born from hemogenic
endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature …

In vertebrates, the first haematopoietic stem cells (HSCs) with multi-lineage and long-term
repopulating potential arise in the AGM (aorta–gonad–mesonephros) region. These HSCs …

BACKGROUND Correct development of the placenta is critical to establishing pregnancy
and inadequate placentation leads to implantation failure and miscarriage, as well as later …

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

In the embryo, the first hematopoietic cells derive from the yolk sac and are thought to be
rapidly replaced by the progeny of hematopoietic stem cells. We used three lineage-tracing …