Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the
pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related …

Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by
heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in …

Compounds with acylhydrazone fragments contain amide and imine groups that can act as
electron donors and acceptors, so they are easier to bind to biological targets and thus …

Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal …

Purpose Matrine (Mat), the main active ingredient of traditional Chinese herbal plant
Sophora flavescens Ait, has significant antitumor effects, but its pharmacological mechanism …

Recent evidence suggests that misfolding, clumping, and accumulation of proteins in the
brain may be common causes and pathogenic mechanism for several neurological …

Matrine alkaloid is a type of Sophora flavescens (Ku Shen) found in plants. It holds excellent
applications for anticancer, antimicrobials, antibacterial, anti pests, and other applications in …

Triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype of
breast cancer, lacks effective treatment options. Sophora flavescens Aiton, a Chinese …

Matrine derivatives were reported to have various biological activities, especially the ester,
amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at …

The constant presence of infectious diseases poses an everlasting threat to the entire world.
In recent years, there has been an increased attention toward the application of traditional …