Besides its broad application in research and biotechnology, genome editing (GE) has great
potential for clinical gene therapy, but delivery of GE tools remains a bottleneck. Whereas …

Clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein
(CRISPR/Cas) system is an adaptable immune mechanism used by many bacteria to protect …

Multidrug-resistance (MDR) featuring complicated and poorly defined mechanisms is a
major obstacle to the success of cancer chemotherapy in the clinic. Compound …

Osteosarcoma is one of the most serious bone malignancies with rapid speed of
deterioration and low survival rate in children and teenagers. Chemotherapy is an important …

Purpose: Osteosarcoma is the most common primary bone cancer and is notorious for
pulmonary metastasis, representing a major threat to pediatric patients. An effective drug …

Osteosarcoma is the most common malignancy in the bone. Current chemotherapy offers
limited efficacy with significant side effects, especially for advanced and relapsed …

In recent years, in situ chemotherapy mediated by biodegradable polymer platforms has
attracted increased attention. Herein, an advanced drug delivery system, combretastatin A-4 …

Polymer nanogels, which are nanosized particles of hydrogels formed by physically or
chemically crosslinking polymers, are one of the most promising nanoplatforms for use in …

Melatonin has been proposed as a potent anticarcinogen presents a short half-life for
osteosarcoma (OS). Cell-in-cell (CIC) structures play a role in the development of malignant …

Aim: Boron nitride nanotubes (BNNTs) and hexagonal boron nitrides (hBNs) are novel
nanostructures with high mechanical strengths, large surface areas and excellent …