Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells
Y Yaniv, AE Lyashkov, S Sirenko, Y Okamoto… - Journal of molecular and …, 2014 - Elsevier
Recent evidence indicates that the spontaneous action potential (AP) of isolated sinoatrial
node cells (SANCs) is regulated by a system of stochastic mechanisms embodied within two …
node cells (SANCs) is regulated by a system of stochastic mechanisms embodied within two …
[HTML][HTML] cAMP-dependent signaling restores AP firing in dormant SA node cells via enhancement of surface membrane currents and calcium coupling
Action potential (AP) firing rate and rhythm of sinoatrial nodal cells (SANC) are controlled by
synergy between intracellular rhythmic local Ca2+ releases (LCRs)(“Ca2+ clock”) and …
synergy between intracellular rhythmic local Ca2+ releases (LCRs)(“Ca2+ clock”) and …
[HTML][HTML] Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad …
D Yang, CH Morrell, AE Lyashkov… - Frontiers in …, 2021 - frontiersin.org
Ca2+ and V m transitions occurring throughout action potential (AP) cycles in sinoatrial
nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating …
nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating …
[HTML][HTML] Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
I Weiser-Bitoun, H Mori, T Nabeshima, N Tanaka… - Scientific Reports, 2023 - nature.com
Average beat interval (BI) and beat interval variability (BIV) are primarily determined by
mutual entrainment between the autonomic-nervous system (ANS) and intrinsic …
mutual entrainment between the autonomic-nervous system (ANS) and intrinsic …
Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells
SG Sirenko, VA Maltsev, Y Yaniv… - American Journal …, 2016 - journals.physiology.org
Coupling of an intracellular Ca2+ clock to surface membrane ion channels, ie, a “membrane
clock,” via coupling of electrochemical Na+ and Ca2+ gradients (E Na and E Ca …
clock,” via coupling of electrochemical Na+ and Ca2+ gradients (E Na and E Ca …
[HTML][HTML] Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development
MG Frasch, DA Giussani - Cells, 2020 - mdpi.com
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated
pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease …
pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease …
Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in …
S Delliaux, M Ichinose, K Watanabe, N Fujii… - … -European Journal of …, 2023 - Springer
Muscle metaboreflex activation during hypercapnia leads to enhanced pressive effects that
are poorly understood while autonomic responses including baroreflex function are not …
are poorly understood while autonomic responses including baroreflex function are not …
[HTML][HTML] Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice
JE Axsom, AP Nanavati, CA Rutishauser, JE Bonin… - Geroscience, 2020 - Springer
Mice are among the most widely used translational models of cardiovascular aging and offer
a method to quickly assess lifespan changes in a controlled environment. The standard …
a method to quickly assess lifespan changes in a controlled environment. The standard …
[HTML][HTML] The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell
Y Yaniv, EG Lakatta - BMB reports, 2015 - ncbi.nlm.nih.gov
Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian
clocks. Specific time scales of different cell types drive their functions: circadian gene …
clocks. Specific time scales of different cell types drive their functions: circadian gene …
[HTML][HTML] Beating rate variability of isolated mammal sinoatrial node tissue: insight into its contribution to heart rate variability
Background Because of the complexity of the interaction between the internal pacemaker
mechanisms, cell interconnected signals, and interaction with other body systems, study of …
mechanisms, cell interconnected signals, and interaction with other body systems, study of …