Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

A wealth of research over the past 2 decades has expanded our understanding of the impact
of early‐life adversity on physiological function and, consequently, health and wellbeing in …

The importance of the modulation of pain by emotion is now widely recognised. In particular,
stress and anxiety, depending on their nature, duration and intensity, can exert potent, but …

Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized
as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia …

ABSTRACT A close association between early‐life experience and cognitive and emotional
outcomes is found in humans. In experimental models, early‐life experience can directly …

Pain in infancy influences pain reactivity in later life, but how and why this occurs is poorly
understood. Here we review the evidence for developmental plasticity of nociceptive …

Abstract Purpose of Review Patients with chronic pain, especially primary or centralized
pain, have elevated rates of psychosocial trauma and intrapersonal or intrapsychic conflict …

Background Experimental stress has been shown to have analgesic as well as allodynic
effect in animals. Despite the obvious negative influence of stress in clinical pain conditions …

Objective Multiple and specific types of childhood adverse events are risk factors for chronic
pain conditions. Although both can covary, no study has evaluated one aspect while …