Precision medicine strives for highly individualized treatments for disease under the notion
that each individual's unique genetic makeup and environmental exposures imprints upon …

Zebrafish (Danio rerio) are aquatic vertebrates with significant homology to their terrestrial
counterparts. While zebrafish have a centuries-long track record in developmental and …

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes
in bone biology, particularly to intramembranous ossification, not captured at other skeletal …

Mutations in the FOXE1 gene are implicated in cleft palate and thyroid dysgenesis in
humans. To investigate whether zebrafish could provide meaningful insights into the …

Amphibians and fish show considerable regeneration potential via dedifferentiation of
somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular …

Bioactive glass nanoparticles (BGNs) are well-recognized multifunctional biomaterials for
bone tissue regeneration due to their capability to stimulate various cellular processes …

The availability of large human datasets for genome-wide association studies (GWAS) and
the advancement of sequencing technologies have boosted the identification of genetic …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …

Osteoporosis is the most prevalent bone condition in the ageing population. This systemic
disease is characterized by microarchitectural deterioration of bone, leading to increased …

Danio rerio is a model organism used to investigate vertebrate development. Manipulation
of the zebrafish genome and resultant gene products by mutation or targeted knockdown …