Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver …

LA Videla, MC Hernandez-Rodas, AH Metherel… - … and Essential Fatty …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFA) play essential roles in cell membrane structure and
physiological processes including signal transduction, cellular metabolism and tissue …

Perspectives in liver redox imbalance: toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone …

LA Videla, R Valenzuela - Biofactors, 2022 - Wiley Online Library
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants,
leading to a disruption of redox signaling and control, and/or molecular damage altering …

Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency

R Valenzuela, AH Metherel, G Cisbani, ME Smith… - Biofactors, 2024 - Wiley Online Library
The synthesis rates of n‐3 and n‐6 polyunsaturated fatty acids (PUFAs) in rodents and
humans are not agreed upon and depend on substrate availability independently of the …

Ferroptosis and metabolic dysfunction‐associated fatty liver disease: Is there a link?

G Feng, CD Byrne, G Targher, F Wang… - Liver …, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD), recently re‐defined and re‐classified as
metabolic dysfunction‐associated fatty liver disease (MAFLD), has become increasingly …

[HTML][HTML] Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/SLC7A11 pathway

T Jiang, Y Xiao, J Zhou, Z Luo, L Yu, Q Liao, S Liu, X Qi… - Redox Biology, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a potentially serious disease that affects 30% of
the global population and poses a significant risk to human health. However, to date, no …

Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population

S Hammouda, I Ghzaiel, W Khamlaoui… - … and Essential Fatty …, 2020 - Elsevier
Polyunsaturated fatty acids (PUFAs) are closely related to various physiological conditions.
In several age-related diseases including Alzheimer's disease (AD) altered PUFAs …

Acute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid in rats

C Batandier, T Poyot, N Marissal-Arvy, K Couturier… - Nutrition Research, 2020 - Elsevier
Studies focusing on the interaction of dietary and acute emotional stress on oxidative stress
in cortex frontal and in brain mitochondria are scarce. Dietary-induced insulin resistance, as …

Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

SA Almatroodi, A Almatroudi, S Anwar… - Journal of Taibah …, 2020 - Taylor & Francis
The current study aimed to investigate the antioxidant, anti-inflammatory and
hepatoprotective activity of olive fruit pulp extract (OFPE) through in vivo-and in vitro-based …

Interaction between iron and omega-3 fatty acids metabolisms: where is the cross-link?

M Ogłuszka, P Lipiński… - Critical Reviews in Food …, 2022 - Taylor & Francis
Iron is an essential micronutrient for almost all living organisms. It plays an important role in
DNA, RNA, and protein synthesis and takes part in electron transport, cellular respiration …

High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat …

A Faradina, SH Tseng, TH Tung, SY Huang, YC Lee… - Food & function, 2021 - pubs.rsc.org
Obesity is associated with an increased risk of an iron deficiency; however, a synergistic
relationship between iron and lipid homeostasis was also observed. The aim of this study …