Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …

Mitochondria are specialized organelles, which serve as the “Power House” to generate
energy for maintaining heart function. These organelles contain various enzymes for the …

Cellular senescence is associated with pleiotropic physiopathological processes, including
aging and age-related diseases. The persistent DNA damage is a major stress leading to …

BACKGROUND: The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in
the cytoplasm, as a denitrosylase enzyme of S-nitrosylation, has been reported in cardiac …

Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …

Abstract Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+
(NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative …

Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of
effective treatments. Interactions between cardiomyocytes and the MI microenvironment …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to
maintain a healthy genome. Dysregulation either in the form of down‐or upregulation in the …